Neurological disorders and traumatic injuries disrupt the bidirectional connection between the brain and the body, resulting in deterioration of both the sensory and motor systems. My long-term research goal is to develop technologies that restore the often-overlooked afferent sensory connection between the body and the brain via a spinal-neural electrical interface.
Spinal cord stimulation (SCS) – an FDA-approved therapy – has been used for chronic pain management for several decades . Several studies have recently explored its potential role in rehabilitation research by showing that SCS can repair injured locomotor circuits in patients with spinal cord injury. Yet the potential role of SCS in treating neurological disorders by directly modulating cortical circuits remains poorly understood. To fill this gap in knowledge and based on an underlying vision — to develop SCS as a novel therapeutic and sensory transmission channel to the brain — I have sought to investigate the following two research questions:
Generating Artificial Sensations with Spinal Cord Stimulation in Primates and Rodentshttps://doi.org/10.1101/2020.05.09.085647
Spinal cord stimulation and rehabilitation in an individual with chronic complete L1 paraplegia due to a conus medullaris injury: motor and functional outcomes at 18 monthshttps://doi.org/10.1101/2020.05.09.085647
A Brain to Spine Interface for Transferring Artificial Sensory Informationhttps://doi.org/10.1038/s41598-020-57617-3
A Closed Loop Brain-machine Interface for Epilepsy Control Using Dorsal Column Electrical Stimulationhttps://doi.org/10.1038/srep32814
Electrical stimulation of the dorsal columns of the spinal cord for Parkinson’s diseasehttps://doi.org/10.1002/mds.27033
Chronic Spinal Cord Electrical Stimulation Protects Against 6-hydroxydopamine Lesionshttps://doi.org/10.1038/srep03839